Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
1.
Med. interna (Caracas) ; 34(1): 53-56, 2018. ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1008281

ABSTRACT

La piel puede ofrecer el primer síntoma guía en el 1% de los pacientes con neoplasias internas. Las manifestaciones cutáneas de malignidades internas se pueden producir por invasión directa de la piel por el tumor y por diseminación metastásica, pero existen mecanismos indirectos que inducen la aparición de signos y síntomas cutáneos no relacionados con el tumor primitivo. El Síndrome de Bazex es una rara dermatosis descrita por Bazex y colaboradores en 1965. Se caracteriza por la presencia de placas eritematosas, psoriasiformes, que típicamente afectan a las manos, los pies, la nariz y los pabellones auriculares. La inexperiencia puede motivar retrasos en el diagnóstico, haciendo que la neoplasia asociada se encuentre en estadios avanzados en el momento del diagnóstico. Se discute un caso clínico de un paciente masculino de 53 años de edad, hipertenso, quien acude por presentar lesiones cutáneas tipo placas hipertróficas, hiperpigmentadas, descamativas y dolorosas con fondo eritematoso acompañados de secreción hialina amarillenta en regiones acrales y cuero cabelludo. La biopsia cutánea reportó granulocitosis y aumento del espesor de la capa córnea; en los cultivos bacteriano y micológico de tejido dérmico creció flora habitual. La biopsia prostática diagnosticó adenocarcinoma prostático Gleason 4/5, Se inició hormonoterapia y se realizó prostatectomía total, con mejoría clínica significativa posterior al inicio del tratamiento. La acroqueratosis de Bazex es un proceso muy infrecuente, con pocos casos descritos en la literatura. Su reconocimiento temprano podría permitir el diagnóstico de la neoplasia asociada en estadios más precoces y conducentes a un tratamiento más temprano(AU)


The skin can show the first symptom in 1% of patients with internal neoplasias. Cutaneous manifestations of internal malignancies can be caused by direct invasion of the skin by the tumor and by metastatic dissemination, but there are indirect mechanisms that induce the appearance of cutaneous signs and symptoms unrelated to the primitive tumor. Bazex Syndrome is a rare dermatosis described by Bazex et al. in 1965. It is characterized by the presence of erythematous, psoriasiform plaques, which typically affect the hands, feet, nose, and ear-lobes. The lack of experience may carry diagnostic delays and the associated neoplasia could be at advanced stages when diagnosed. We describe here the case of a 53-year-old male patient, who consulted for cutaneous lesions.These were hypertrophic, hyperpigmented, scaly and painful plaques with an erythematous background accompanied by a yellowish hyaline secretion in the hands, feet and scalp. A skin biopsy was done that reported granulocytosis and increased thickness of the corneal layer; in addition, bacterial and mycological culture of dermal tissue were negative. The prostate biopsy diagnosed a prostate adenocarcinoma, Gleason 4/5. Hormone therapy was started and total prostatectomy was performed, with significant clinical improvement .Bazex acroqueratosis is a very rare process, with few cases described in the literature. Its early recognition could allow the diagnosis of the associated neoplasia in earlier stages, leading to earlier treatment(AU)


Subject(s)
Humans , Male , Middle Aged , Prostatic Neoplasms/physiopathology , Skin Diseases/etiology , Carcinoma, Squamous Cell/physiopathology , Immune System , Internal Medicine
2.
GED gastroenterol. endosc. dig ; 31(2): 75-77, abr.-jun. 2012. ilus
Article in Portuguese | LILACS | ID: lil-698378

ABSTRACT

A síndrome de Bazex é uma dermatose paraneoplásica caracterizada por lesões cutâneas associadas a neoplasias subjacentes. Frequentemente é um marcador precoce das neoplasias subclínicas. É uma doença rara, presente nos pacientes com neoplasias dos tratos respiratórios e digestivo superiores. Relatamos o caso de um homem portador da síndrome de Bazex associado a carcinoma de células escamosas do esôfago.


Bazex syndrome is a paraneoplastic dermatosis characterized by cutaneous lesions with an underlying neoplasmas. With a high frequency is the earliest marker of an underlying subclinical neoplasm. Is a rare disease and is uncommon even in pacientes withupper tract aerodigestive tract cancer. We report a case of a male with Bazex syndrome associated a squamous cell esophageal cancer.


Subject(s)
Humans , Male , Middle Aged , Paraneoplastic Syndromes , Esophageal Neoplasms , Skin Diseases , Carcinoma
3.
Annals of Dermatology ; : 216-220, 2008.
Article in English | WPRIM | ID: wpr-117031

ABSTRACT

Acrokeratosis paraneoplastica, or Bazex syndrome, is one of the paraneoplastic syndromes. The characteristic skin lesions include palmoplantar keratoderma, psoriasiform skin lesions, hyperpigmentation, and nail dystrophy. The most common associated neoplasms are squamous cell carcinoma of the upper respiratory tract and other kinds of tumors with cervical lymph node metastasis. A 63-year-old woman presented with an 11 month history of hyperkeratotic lesions on the palms and soles. Ten months before she had been diagnosed with adenocarcinoma of the colon and undergone a left hemicolectomy. We report a case of acrokeratosis paraneoplastica associated with colon cancer which persisted after removal of the primary cancer, but resolved with topical tretinoin treatment.


Subject(s)
Female , Humans , Middle Aged , Adenocarcinoma , Carcinoma, Basal Cell , Carcinoma, Squamous Cell , Colon , Colonic Neoplasms , Histiocytoma, Benign Fibrous , Hyperpigmentation , Hypotrichosis , Keratoderma, Palmoplantar , Lymph Nodes , Nails , Neoplasm Metastasis , Paraneoplastic Syndromes , Respiratory System , Skin , Skin Neoplasms , Tretinoin
SELECTION OF CITATIONS
SEARCH DETAIL